User profiles for Neil R. Cashman
 | Neil CashmanUniversity of British Columbia Verified email at vch.ca Cited by 21701 |
Neuroblastoma× spinal cord (NSC) hybrid cell lines resemble developing motor neurons
NR Cashman, HD Durham, JK Blusztajn… - Developmental …, 1992 - Wiley Online Library
We have developed a series of mouse‐mouse neural hybrid cell lines by fusing the
aminopterin‐sensitive neuroblastoma N18TG2 with motor neuron‐enriched embryonic day 12–14 …
aminopterin‐sensitive neuroblastoma N18TG2 with motor neuron‐enriched embryonic day 12–14 …
[HTML][HTML] Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels
In late 1987 there was an outbreak in Canada of gastrointestinal and neurologic symptoms
after the consumption of mussels found to be contaminated with domoic acid, which is …
after the consumption of mussels found to be contaminated with domoic acid, which is …
[HTML][HTML] Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
…, H Mitsumoto, RC Petersen, NR Cashman… - PLoS …, 2008 - journals.plos.org
The TAR DNA-binding protein 43 (TDP-43) has been identified as the major disease protein
in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin …
in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin …
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and-independent mechanisms
…, IR Mackenzie, NR Cashman - Proceedings of the …, 2014 - National Acad Sciences
Amyotrophic lateral sclerosis (ALS) is predominantly sporadic, but associated with heritable
genetic mutations in 5–10% of cases, including those in Cu/Zn superoxide dismutase (SOD1…
genetic mutations in 5–10% of cases, including those in Cu/Zn superoxide dismutase (SOD1…
Cellular isoform of the scrapie agent protein participates in lymphocyte activation
NR Cashman, R Loertscher, J Nalbantoglu, I Shaw… - Cell, 1990 - cell.com
The scrapie agent protein (Sp33-37 or PrPSC) is the disease-associated isoform of a normal
cellular membrane protein (Cp33-37 or PrPc) of unknown function. We report that normal …
cellular membrane protein (Cp33-37 or PrPc) of unknown function. We report that normal …
[HTML][HTML] Monomeric Cu, Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral …
…, JR Lepock, LH Kondejewski, NR Cashman… - Journal of Biological …, 2004 - ASBMB
Proteinacious intracellular aggregates in motor neurons are a key feature of both sporadic
and familial amyotrophic lateral sclerosis (ALS). These inclusion bodies are often …
and familial amyotrophic lateral sclerosis (ALS). These inclusion bodies are often …
[HTML][HTML] Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis
…, S Dahan, XF Qi, JP Crow, NR Cashman… - Journal of Biological …, 2002 - ASBMB
The presence of intracellular aggregates that contain Cu/Zn superoxide dismutase (SOD1)
in spinal cord motor neurons is a pathological hallmark of amyotrophic lateral sclerosis (ALS). …
in spinal cord motor neurons is a pathological hallmark of amyotrophic lateral sclerosis (ALS). …
Multiple sclerosis: Fas signaling in oligodendrocyte cell death
…, B Bonetti, V Balasingam, NR Cashman… - The Journal of …, 1996 - rupress.org
Fas is a cell surface receptor that transduces cell death signals when cross-linked by agonist
antibodies or by fas ligand. In this study, we examined the potential of fas to contribute to …
antibodies or by fas ligand. In this study, we examined the potential of fas to contribute to …
Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria
…, TM Miller, NR Cashman… - Proceedings of the …, 2008 - National Acad Sciences
Mutations in copper/zinc superoxide dismutase (SOD1) are causative for dominantly inherited
amyotrophic lateral sclerosis (ALS). Despite high variability in biochemical properties …
amyotrophic lateral sclerosis (ALS). Despite high variability in biochemical properties …
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells
…, SS Plotkin, NR Cashman - Proceedings of the …, 2011 - National Acad Sciences
Human wild-type superoxide dismutase-1 (wtSOD1) is known to coaggregate with mutant
SOD1 in familial amyotrophic lateral sclerosis (FALS), in double transgenic models of FALS, …
SOD1 in familial amyotrophic lateral sclerosis (FALS), in double transgenic models of FALS, …
