Idiosyncratic drug reactions are unpredictable reactions that can result in significant morbidity
and mortality. Severe idiosyncratic drug reactions are often characterised by fever and …

Although the anticonvulsant hypersensitivity syndrome was first described in 1950,
confusion still abounds regarding the syndrome. The triad of fever, rash and internal organ …

Objective To systematically review evidence on genetic risk factors for carbamazepine (
CBZ )–induced hypersensitivity reactions ( HSR s) and provide practice recommendations …

• Background and Design.— To conduct a prospective case-control study about causative
factors of severe bullous erythema multiforme, Stevens-Johnson syndrome, and toxic …

Arene oxide metabolites of aromatic anticonvulsants (phenytoin, phenobarbital, and
carbamazepine) may be involved in the pathogenesis of hypersensitivity reactions. We investigated …

Drug hypersensitivity syndrome (DHS) is a severe idiosyncratic reaction associated with
drug therapy. Cutaneous eruptions are the most common idiosyncratic reaction to drugs, but …

Individual differences in metabolism of the sulfonamides may predispose patients to idiosyncratic
reactions. Sulfonamides are metabolized by N-acetylation (mediated by a genetically …

Background: Minocycline has been reported to cause serious, albeit rare, adverse events,
including serum sickness—like reaction, hypersensitivity syndrome reaction, and drug-…

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening,
immunologically mediated, and usually drug-induced disease with a high burden to individuals, …

The objective of this study is to identify gender‐related differences in the types of symptoms
and drugs reported to cause an adverse drug reaction. Patient data from the Sunnybrook …