Background Checkpoint inhibitors (CPIs) have revolutionized the treatment of cancer, but
their use remains limited by off-target inflammatory and immune-related adverse events. Solid …

Melanoma is usually apparent on the skin and readily detected by trained medical providers
using a routine total body skin examination, yet this malignancy is responsible for the …

Background— Out-of-hospital cardiac arrest (OHCA) is associated with a poor prognosis
and poses a significant burden to the healthcare system, but few studies have evaluated …

Preclinical studies suggest that treatment with neoadjuvant immune checkpoint blockade is
associated with enhanced survival and antigen-specific T cell responses compared with …

Importance Extramammary Paget disease (EMPD) is a frequently recurring malignant
neoplasm with metastatic potential that presents in older adults on the genital, perianal, and …

During a search for methods to prepare 4-alkyl-substituted L-prolines to support our
ongoing ACE program1, we reported a procedure2 involving the interaction of lithium …

BACKGROUND: Approximately 16% of clinically confirmed pregnancies end in miscarriage.
However, there is frequently no routine follow-up by the primary healthcare team (PHCT) to …

Targeting nanoparticles by conjugating various specific ligands has shown potential
therapeutic efficacy in nanomedicine. However, poor penetration of antitumor drugs into solid …

Background: Neoadjuvant checkpoint inhibition (CPI) has recently demonstrated impressive
outcomes in patients with stage 3 cutaneous melanoma. However, the safety, efficacy, and …

Simple Summary Non-melanomatous skin cancer (NMSC) is the most incident malignancy
worldwide, and management can be difficult in the locally advanced setting. Here, we …