Background A large outbreak of the hemolytic–uremic syndrome caused by Shiga-toxin–producing
Escherichia coli O104:H4 occurred in Germany in May 2011. The source of infection …

Aims The primary safety and efficacy endpoints of the randomized FIRE AND ICE trial have
recently demonstrated non-inferiority of cryoballoon vs. radiofrequency current (RFC) …

Background Drug-coated balloons (DCB) are a novel therapeutic strategy for small native
coronary artery disease. However, their safety and efficacy is poorly defined in comparison …

Background In the treatment of de-novo coronary small vessel disease, drug-coated balloons
(DCBs) are non-inferior to drug-eluting stents (DESs) regarding clinical outcome up to 12 …

… Kühne and Osswald are joint senior authors and contributed … Kühne and Osswald are joint
senior authors and contributed … Kühne has received consultant fees from Bayer, Boehringer …

The incidence of tetracycline residues in commercially available samples of meat meals and
meat and bone meals was investigated. Four diVerent methods were used on each of the …

Aims We aimed to investigate the association of clinically overt and silent brain lesions with
cognitive function in atrial fibrillation (AF) patients. Methods and results We enrolled 1227 AF …

BACKGROUND: Cryoballoon ablation has emerged as a novel treatment strategy for
patients with atrial fibrillation (AF). OBJECTIVE: The purpose of this study was to compare …

Aims Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice,
and its paroxysmal nature makes its detection challenging. In this trial, we evaluated a novel …

Excessive alcohol consumption is one of the main causes of death and disability worldwide.
Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of …