Background: Delirium is common and often goes undetected in older patients admitted to
medical services. It is associated with poor outcomes. We conducted a randomized clinical trial …

OBJECTIVE: To assess a systematic intervention in cases of delirium in elderly inpatients.
DESIGN: Randomized, controlled trial. SETTING: University-affiliated, primary acute care …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

Genome-wide association studies have revealed numerous risk loci associated with diverse
diseases. However, identification of disease-causing variants within association loci …

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

To the Editor: Physical examination of patients with cachexia, in particular auscultation of
the heart and lungs, is challenging for clinicians. This is partly caused by the prominence of …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL)
cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower …

Upstream open reading frames (uORFs) are important tissue-specific cis-regulators of protein
translation. Although isolated case reports have shown that variants that create or disrupt …

OBJECTIVE Recent genome-wide association studies have revealed loci associated with
glucose and insulin-related traits. We aimed to characterize 19 such loci using detailed …