User profiles for Michael B. Coulthart
Michael CoulthartHead, CJDSS, Public Health Agency of Canada Verified email at canada.ca Cited by 1838 |
Rapid and sensitive RT-QuIC detection of human Creutzfeldt-Jakob disease using cerebrospinal fluid
Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing
patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) …
patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) …
Cellular prion protein is released on exosomes from activated platelets
C Robertson, SA Booth, DR Beniac, MB Coulthart… - Blood, 2006 - ashpublications.org
Cellular prion protein (PrP C ) is a glycophosphatidylinositol (GPI)–anchored protein, of
unknown function, found in a number of tissues throughout the body, including several blood …
unknown function, found in a number of tissues throughout the body, including several blood …
[HTML][HTML] Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study
MB Coulthart, GH Jansen, E Olsen, DL Godal… - BMC neurology, 2011 - Springer
Background To better characterize the value of cerebrospinal fluid (CSF) proteins as diagnostic
markers in a clinical population of subacute encephalopathy patients with relatively low …
markers in a clinical population of subacute encephalopathy patients with relatively low …
Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study
Background Human prion diseases are rare and usually rapidly fatal neurodegenerative
disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD). Variants in the …
disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD). Variants in the …
[HTML][HTML] The prion protein modulates A-type K+ currents mediated by Kv4. 2 complexes through dipeptidyl aminopeptidase-like protein 6
…, J Yang, NR Cashman, MB Coulthart… - Journal of Biological …, 2013 - ASBMB
Widely expressed in the adult central nervous system, the cellular prion protein (PrP C ) is
implicated in a variety of processes, including neuronal excitability. Dipeptidyl aminopeptidase…
implicated in a variety of processes, including neuronal excitability. Dipeptidyl aminopeptidase…
[HTML][HTML] Molecular, biochemical and genetic characteristics of BSE in Canada
…, C Graham, M Czub, TA McAllister, MB Coulthart… - PLoS …, 2010 - journals.plos.org
The epidemiology and possibly the etiology of bovine spongiform encephalopathy (BSE)
have recently been recognized to be heterogeneous. In particular, three types [classical (C) …
have recently been recognized to be heterogeneous. In particular, three types [classical (C) …
Differing amounts of genetic polymorphism in testes and male accessory glands ofDrosophila melanogaster andDrosophila simulans
MB Coulthart, RS Singh - Biochemical genetics, 1988 - Springer
We surveyed genetic polymorphism by two-dimensional gel electrophoresis of male
reproductive tract proteins in 20 isofemale lines each ofDrosophila melanogaster andDrosophila …
reproductive tract proteins in 20 isofemale lines each ofDrosophila melanogaster andDrosophila …
Comparative analysis of a recombining-repeat-sequence family in the mitochondrial genomes of wheat (Triticum aestivum L.) and rye (Secale cereale L.)
MB Coulthart, DF Spencer, MW Gray - Current genetics, 1993 - Springer
The mitochondrial genomes of wheat and rye each contain a three-member family of
recombining repeat peat sequences (the “18S/5S repeat”) that encode genes for 18S and 5S …
recombining repeat peat sequences (the “18S/5S repeat”) that encode genes for 18S and 5S …
Serogroup B, Electrophoretic Type 15 Neisseria meningitidis in Canada
DA Kertesz, MB Coulthart, JA Ryan… - Journal of Infectious …, 1998 - academic.oup.com
Invasive meningococcal disease is nationally reportable in Canada. In recent years, a
serogroup C genotype, designated electrophoretic type 15 (ET15), has been the most frequently …
serogroup C genotype, designated electrophoretic type 15 (ET15), has been the most frequently …
[HTML][HTML] Development of an automated capillary immunoassay to detect prion glycotypes in Creutzfeldt-Jakob disease
…, A Peterson, D Knox, GH Jansen, MB Coulthart… - Laboratory …, 2023 - Elsevier
Creutzfeldt-Jakob disease (CJD) comprises a group of transmissible neurodegenerative
diseases with vast phenotypic diversity. Sporadic CJD heterogeneity is predominantly …
diseases with vast phenotypic diversity. Sporadic CJD heterogeneity is predominantly …