Large language models (LLMs) have been shown to be able to perform new tasks based on
a few demonstrations or natural language instructions. While these capabilities have led to …

High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2
diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by …

Shortly after the cellular mechanism of RNA interference (RNAi) was first described, scientists
began using this powerful technique to study gene function. This included designing better …

The interplay between innate and adaptive immunity is important in multiple sclerosis (MS).
The inflammasome complex, which activates caspase-1 to process pro–IL-1β and pro–IL-18, …

Bacterial infection elicits a range of beneficial as well as detrimental host inflammatory
responses. Key among these responses are macrophage/monocyte necrosis, release of the …

Neisseria gonorrhoeae is a common sexually transmitted pathogen that significantly impacts
female fertility, neonatal health, and transmission of HIV worldwide. N. gonorrhoeae usually …

Acute inflammation in response to both exogenous and endogenous danger signals can
lead to the assembly of cytoplasmic inflammasomes that stimulate the activation of caspase-1. …

The nucleotide-binding domain leucine-rich repeat-containing proteins, NLRs, are intracellular
sensors of pathogen-associated molecular patterns and damage-associated molecular …

The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for
effective host defense against microbial pathogens. Recent discoveries have uncovered a …

Periodontal disease is a chronic inflammatory disorder that leads to the destruction of tooth-supporting
tissue and affects 10–20 million people in the US alone. The oral pathogen …