Drs. Yoshimura and Yoon1 give a lucid description of the potentially lethal consequences of
community-acquired infection in the setting of asplenia. However, they do not highlight …

Yoshimura and Yoon describe lucidly the potentially lethal consequences of community
acquired infection in the setting of asplenia. However, they do not highlight measures to …

Children with congenital or acquired asplenia or hyposplenism have an increased risk for
severe and even life-threatening infections mainly due to encapsulated bacteria. Current …

Isolated congenital asplenia is a rare condition that mostly manifests in the early years,
usually due to fatal systemic infections. In this paper, however, we present a case of a 36 …

Introduction Asplenia, the absence of normal spleen function, may be congenital or acquired
(Rubin & Schaffner 2014). The spleen plays an important role in immune response …

Children with asplenia or hyposplenia are at risk of developing overwhelming sepsis. Health
care providers caring for children with asplenia should ensure the best outcomes by using …

Congenital asplenia is a rare disorder commonly associated with other visceral and cardiac
congenital anomalies. Isolated congenital asplenia is even less common than syndromic …

Acute infectious purpura fulminans (AIPF) is characterized by rapidly progressive ischemic
necrosis of the extremities, disseminated intravascular coagulopathy and multiorgan failure …

The lifetime risk of dying from sepsis is approximately 2-3% in persons with (functional)
asplenia. Both patients and their physicians are not always fully aware of these risks and the …

Background Overwhelming post-splenectomy infection (OPSI) is a serious complication of
asplenia. Clinical guidelines recommend numerous measures to reduce the risk of OPSI, but …