Previous studies in this laboratory established that low density lipoprotein (LDL) incubated
with cultured endothelial cells, smooth muscle cells, or macrophages undergoes free radical-…

Botanical polysaccharides exhibit a number of beneficial therapeutic properties, and it is
thought that the mechanisms involved in these effects are due to the modulation of innate …

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

Background— NAD(P)H oxidases are important sources of superoxide in the vasculature,
the activity of which is associated with risk factors for human atherosclerosis. This study was …

Native low density lipoprotein (LDL) does not affect monocyte/macrophage motility. On the
other hand, oxidatively modified LDL inhibits the motility of resident peritoneal macrophages …

Objective Anti–tumor necrosis factor α agents are among the most effective therapies for
rheumatoid arthritis (RA). However, their optimal use is yet to be determined. This 12‐month …

Heart failure and hypertension have each been linked to an induction of oxidative stress
transduced by neurohormones, such as angiotensin II and catecholamines. Herein, we …

A major source of vascular smooth muscle cell (VSMC) superoxide is NAD(P)H oxidase.
However, the molecular characteristics and regulation of this enzyme are unclear. We …

Objective— Reactive oxygen species (ROS) that act as signaling molecules in vascular
smooth muscle cells (VSMC) and contribute to growth, hypertrophy, and migration in …

Neutrophils play an essential role in the body's innate defense against pathogens and are
one of the primary mediators of the inflammatory response. To defend the host, neutrophils …