Bailey and colleagues 1 are to be commended for highlighting the potential of many
medications to interact with grapefruit. 1 However, one medication on their list (Table 1 1) …

We are very concerned that statements made in a review article that appeared in CMAJ1 do
not correctly reflect the current state of medical and scientific understanding of the topic of …

We are very concerned that statements made in a review article that appeared in CMAJ1 do
not correctly reflect the current state of medical and scientific understanding of the topic of …

Cytochrome P450 (CYP) enzymes, including CYP2C19 and CYP3A4, participate in the
bioactivation of clopidogrel. Grapefruit juice constituents potently inactivate intestinal …

Iwas glad to see James Maskalyk's re-view of grapefruit and drug interactions, 1 as I have
been concerned for some time about the need to increase awareness of this issue. 2, 3 …

Grapefruit juice, which is widely consumed for its positive health benefits, can have severe,
sometimes fatal, interactions with drugs. This phenomenon was first identified …

What to do: Much of the data obtained on grapefruit juice–drug interactions involved
measuring serum drug concentrations in small numbers of healthy volunteers. Because of …

Questions about the interaction of drugs with grapefruit juice have increased. I have
therefore collated available data to produce a table which may help when assessing the …

Numerous reports have documented drug interactions with grapefruit juice (GFJ) that occur
via inhibition of CYP3A enzymes. As reported by Glaeser et al. 1 in the March 2007 issue of …

Background Grapefruit juice impacts the metabolism of a number of drugs via inhibition of a
variety of metabolic enzymes. This study evaluated the impact of grapefruit juice on the …