User profiles for Mamoru Watanabe

Mamoru Watanabe

Tokyo Medical and Dental University
Verified email at tmd.ac.jp
Cited by 27790

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

…, R Okamoto, K Tsuchiya, H Clevers, M Watanabe - Nature medicine, 2012 - nature.com
Adult stem-cell therapy holds promise for the treatment of gastrointestinal diseases. Here
we describe methods for long-term expansion of colonic stem cells positive for leucine-rich …

Macromolecule-like aspects for a colloidal suspension of an exfoliated titanate. Pairwise association of nanosheets and dynamic reassembling process initiated from it

T Sasaki, M Watanabe, H Hashizume… - Journal of the …, 1996 - ACS Publications
A layered protonic titanate of lepidocrocite-type, H x Ti 2-x/4 □ x /4 O 4 ·H 2 O (x ∼ 0.7; □,
vacancy), has been exfoliated on the action of an aqueous solution of tetrabutylammonium (…

Redoxable Nanosheet Crystallites of MnO2 Derived via Delamination of a Layered Manganese Oxide

…, T Sasaki, Wang, M Watanabe - Journal of the American …, 2003 - ACS Publications
This paper reports on the swelling and exfoliation behavior of a layered protonic manganese
oxide, H 0.13 MnO 2 ·0.7H 2 O, in a solution of tetrabutylammonium (TBA) hydroxide and …

Osmotic swelling to exfoliation. Exceptionally high degrees of hydration of a layered titanate

T Sasaki, M Watanabe - Journal of the American Chemical …, 1998 - ACS Publications
This paper describes the swelling/exfoliation process in which a layered protonic titanate, H
x Ti 2 - x /4 □ x /4 O 4 ·H 2 O (x ∼ 0.7; □, vacancy), undergoes high degrees of hydration in …

[HTML][HTML] Evidence-based clinical practice guidelines for inflammatory bowel disease 2020

…, M Esaki, K Sugimoto, T Fuji, K Watanabe… - Journal of …, 2021 - Springer
Inflammatory bowel disease (IBD) is a general term for chronic or remitting/relapsing inflammatory
diseases of the intestinal tract and generally refers to ulcerative colitis (UC) and Crohn’…

Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial

…, X Liu, CH Hsueh, C Tasset, R Besuyen, M Watanabe… - The Lancet, 2021 - thelancet.com
Background The global prevalence of ulcerative colitis is increasing, and induction and
maintenance of remission is a crucial therapeutic goal. We assessed the efficacy and safety of …

Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract

…, S Okamoto, Y Ikeda, T Hibi, J Inazawa, M Watanabe - Nature medicine, 2002 - nature.com
Studies have shown that bone marrow cells have the potential to differentiate into a variety of
cell types. Here we show that bone marrow cells can repopulate the epithelia of the human …

[HTML][HTML] Evidence-based clinical practice guidelines for inflammatory bowel disease

…, K Watanabe, T Hibi, Y Suzuki, M Watanabe… - Journal of …, 2018 - Springer
Inflammatory bowel disease (IBD) is a chronic disorder involving mainly the intestinal tract,
but possibly other gastrointestinal and extraintestinal organs. Although etiology is still …

[PDF][PDF] YAP/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration

…, Y Li, CD Madsen, T Nakamura, M Watanabe… - Cell stem cell, 2018 - cell.com
Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is
currently unclear how this is orchestrated at the cellular level and how cell fate is affected by …

Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.

M Watanabe, Y Ueno, T Yajima, Y Iwao… - The Journal of …, 1995 - Am Soc Clin Investig
The interaction of mucosal lymphocytes and intestinal epithelial cells is thought to be
important in regulating immune response in the intestinal mucosa, but conclusive evidence is …