Introdução: Há diversas terapias sendo utilizadas, consideradas ou propostas para o tratamento
da COVID-19, muitas carecendo de apropriada avaliação de efetividade e segurança. …

Background: Although several tools to evaluate the credibility of health care guidelines exist,
guidance on practical steps for developing guidelines is lacking. We systematically …

Background Hydroxychloroquine and azithromycin have been used to treat patients with
coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these …

Background Single group data present unique challenges for synthesises of evidence.
Proportional meta-analysis is becoming an increasingly common technique employed for the …

Background There is a notable lack of methodological and reporting guidance for systematic
reviews of prevalence data. This information void has the potential to result in reviews that …

The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE)
approach defines quality of evidence as confidence in effect estimates; this conceptualization …

Background Guideline developers can: (1) adopt existing recommendations from others; (2)
adapt existing recommendations to their own context; or (3) create recommendations de …

… Robinson’s and Falavigna’s institutions received funding from the Brazilian Ministry of
Health. Dr. Falavigna disclosed that he is an associate of a consulting and training company in …

Objectives: To evaluate the effect of an extended visitation model compared with a restricted
visitation model on the occurrence of delirium among ICU patients. Design: Prospective …

Objetivo: Avaliar a prevalência de incapacidades físicas, cognitivas e psiquiátricas, fatores
associados e sua relação com qualidade de vida em pacientes sobreviventes de internação …