Since the first attempts to use standardised methods for sampling induced airways sputum,
two methods for processing the expectorate have evolved. The first involves selecting all …

One of the most important recent advances in the investigation of airway inflammation has
been the introduction of sputum induction by inhalation of an aerosol of hypertonic saline, by …

Background Depression is frequently reported in association with COPD. However, the
prevalence of depression in these patients ranges largely. This study aimed to systematically …

… Sputum selected from saliva was processed within 2 h as described by Pizzichini and
colleagues (14). Briefly, sputum was treated by adding four volumes of 0.1% dithiothreitol (DTT) (…

Background Eosinophilic inflammation, which may be a consequence of interleukin-5 action,
is a characteristic feature of some forms of asthma. However, in three previous clinical trials …

The role of inhaled corticosteroids in the management of chronic obstructive pulmonary
disease (COPD) remains controversial. The purpose of this study was to evaluate whether …

We examined the feasibility of using induced sputum to evaluate the airway inflammatory
response to natural acute respiratory virus infections. We recruited eight asthmatics and nine …

Background The COPD Assessment Test (CAT) was developed as a simple instrument to
assess health status in patients with COPD. This study aimed to systematically review the …

Background: Asthma phenotypes are well described among children. However, there are
few studies comparing airway inflammation in different clinical presentations of pediatric …

BACKGROUND: Inhaled corticosteroids are effective in suppressing a chronic cough without
asthma associated with sputum eosinophilia. OBJECTIVE: To investigate the inflammatory …