Introduction Allogeneic hematopoietic stem cell transplant (HSCT) and gene therapy (GT)
are two potentially curative approaches for sickle cell disease (SCD), but they have never …

… links open overlay panel Lianne E. Rotin a , Katerina Pavenski b c , Andrew Petrosoniak
d e … At the postgraduate level, TM education is often delivered through e-learning and on-the-job …

Targeting Bruton's tyrosine kinase (BTK) with the small molecule BTK inhibitor ibrutinib has
significantly improved patient outcomes in several B-cell malignancies, with minimal toxicity. …

Discussion We present a case of a 30-year-old man with nonresolving pneumonia. Besides
radiographic findings, his blood work and physical examination were largely normal, leading …

BACKGROUND: Despite advancements in medical therapy and supportive care for sickle
cell disease (SCD) over the last several decades, disease morbidity and mortality remain …

Ibrutinib is a small-molecule Bruton’s tyrosine kinase (BTK) inhibitor yielding impressive
clinical responses in B-cell malignancies, where BTK contributes to disease development and …

Bruton’s tyrosine kinase (BTK) is a potential therapeutic target in acute myeloid leukemia (AML)
and the small molecule BTK inhibitor ibrutinib has been found to potentiate the cytotoxic …

The epidermal growth factor receptor (EGFR) inhibitor erlotinib has demonstrated significant
EGFR-independent activity against acute myeloid leukemia (AML) cell lines and primary …

Sonic Hedgehog and its GLI transcriptional effectors control foliation complexity during
cerebellar morphogenesis by promoting granule cell precursor proliferation. Here, we reveal a …

DNA copy-number variations (CNVs) underlie many neuropsychiatric conditions, but they
have been less studied in cancer. We report the association of a 17p13.1 CNV, childhood-…