Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs)
on hydroxychloroquine/chloroquine, which currently face recruitment challenges or …

Aims/hypothesis The aim of this cohort study was to investigate the risk of malignant neoplasms
and mortality in patients with diabetes treated either with human insulin or with one of …

Objective To assess differences in estimated treatment effects for mortality between observational
studies with routinely collected health data (RCD; that are published before trials are …

Background Air pollution is hypothesized to be a risk factor for diabetes. Epidemiological
evidence is inconsistent and has not been systematically evaluated. Objectives We …

Importance Convalescent plasma is a proposed treatment for COVID-19. Objective To assess
clinical outcomes with convalescent plasma treatment vs placebo or standard of care in …

Aims With the success of antiretroviral therapy (ART), non-human immunodeficiency virus (HIV)-related
comorbidities like cardiovascular diseases (CVDs) are of increasing concern. …

In pharmacoepidemiology, routinely collected data from electronic health records (including
primary care databases, registries, and administrative healthcare claims) are a resource for …

Importance The discontinuation of randomized clinical trials (RCTs) raises ethical concerns
and often wastes scarce research resources. The epidemiology of discontinued RCTs, …

Importance Feedback interventions using routinely collected health data might reduce antibiotic
use nationwide without requiring the substantial resources and structural efforts of other …

Extensive resources have been invested in this field: they include the set-up of disease
registries and clinical databases at regional, national or international levels; the promotion of the …