Background: Recent lipid guidelines recommend aggressive low-density lipoprotein (LDL)
cholesterol lowering in patients with coronary artery disease. To clarify the evidence for this …

Objectives: The purpose of this study was to conduct a meta-analysis that compares the
reduction of cardiovascular outcomes with high-dose statin therapy versus standard dosing …

Background: Intensive statin therapy reduces major adverse cardiovascular events (MACE),
but the effect on mortality is unclear. Objective: To determine whether intensive statin …

Aims Statin therapy is associated with important benefits for patients at risk of, and with,
established cardiovascular disease. There is widespread interest in whether intensive …

Purpose To reveal and evaluate the efficacy and safety of intensive statin therapy in older
patients (age≥ 65 years) with coronary heart disease (CHD). Methods Electronic databases …

Importance In patients with coronary artery disease, some guidelines recommend initial
statin treatment with high-intensity statins to achieve at least a 50% reduction in low-density …

Background Lowering of LDL cholesterol with standard statin regimens reduces the risk of
occlusive vascular events in a wide range of individuals. We aimed to assess the safety and …

Background—Recent clinical trials found that high-dose statin therapy, compared with
conventional-dose statin therapy, reduces the risk of cardiovascular events in patients with …

BACKGROUND:: Randomized trials evaluating intensive dose statin therapy have found
enhanced protection against cardiovascular (CV) events compared with moderate-dose …

Recent clinical trials recommend achieving a low-density lipoprotein cholesterol level of<
100 mg/dl in high-risk and< 70 mg/dl in very high risk patients. To attain these goals …