Effect of empagliflozin on left ventricular mass in patients with type 2 diabetes mellitus and coronary artery disease: the EMPA-HEART CardioLink-6 randomized …
Background: SGLT2 (sodium-glucose cotransporter 2) inhibitors lower cardiovascular events
in type 2 diabetes mellitus but whether they promote direct cardiac effects remains unknown…
in type 2 diabetes mellitus but whether they promote direct cardiac effects remains unknown…
Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise
Background: There is evidence that ultra-endurance exercise causes myocardial injury. The
extent and duration of these changes remains unresolved. Recent reports have speculated …
extent and duration of these changes remains unresolved. Recent reports have speculated …
Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience
Rationale: Altered cardiac energetics is known to play an important role in the progression
toward heart failure. A noninvasive method for imaging metabolic markers that could be used …
toward heart failure. A noninvasive method for imaging metabolic markers that could be used …
Transcatheter versus medical treatment of patients with symptomatic severe tricuspid regurgitation
…, P Lurz, D Braun, E Brochet, KA Connelly… - Journal of the American …, 2019 - jacc.org
Background : Tricuspid regurgitation is associated with increased rates of heart failure (HF)
and mortality. Transcatheter tricuspid valve interventions (TTVI) are promising, but the clinical …
and mortality. Transcatheter tricuspid valve interventions (TTVI) are promising, but the clinical …
Effect of empagliflozin on erythropoietin levels, iron stores, and red blood cell morphology in patients with type 2 diabetes mellitus and coronary artery disease
CD Mazer, GMT Hare, PW Connelly, RE Gilbert… - Circulation, 2020 - Am Heart Assoc
A, EPO levels in patients receiving empagliflozin 10 mg daily (red circles) or placebo (blue
squares) plotted as mean±95% CIs. Adjusted differences are betweengroup differences in …
squares) plotted as mean±95% CIs. Adjusted differences are betweengroup differences in …
Outcomes after current transcatheter tricuspid valve intervention: mid-term results from the international TriValve registry
…, L Biasco, D Braun, E Brochet, KA Connelly… - JACC: Cardiovascular …, 2019 - jacc.org
Objectives : A large, prospective international registry was developed to evaluate the initial
clinical applications of transcatheter tricuspid valve intervention (TTVI) with different devices. …
clinical applications of transcatheter tricuspid valve intervention (TTVI) with different devices. …
The (Pro)Renin Receptor: Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney
…, AJ Cox, KE White, SL Advani, K Thai, KA Connelly… - …, 2009 - Am Heart Assoc
The (pro)renin receptor ([P]RR) is a transmembrane protein that binds both renin and
prorenin with high affinity, increasing the catalytic cleavage of angiotensinogen and signaling …
prorenin with high affinity, increasing the catalytic cleavage of angiotensinogen and signaling …
Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: an important clue to the EMPA-REG OUTCOME trial?
…, A Sabongui, H Teoh, CD Mazer, KA Connelly - Diabetes …, 2016 - Am Diabetes Assoc
Amid the excitement over the results of the BI 10773 (Empagliflozin) Cardiovascular Outcome
Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial (1), the …
Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial (1), the …
Right ventricular-pulmonary arterial coupling and afterload reserve in patients undergoing transcatheter tricuspid valve repair
…, D Kalbacher, R Estevez-Loureiro, KA Connelly… - Journal of the American …, 2022 - jacc.org
Background The right ventricular (RV)–pulmonary arterial (PA) coupling ratio relates the
efficiency with which RV stroke work is transferred into the PA. Lower ratios indicate an …
efficiency with which RV stroke work is transferred into the PA. Lower ratios indicate an …
Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart
Hyperpolarization of spins via dynamic nuclear polarization (DNP) has been explored as a
method to non‐invasively study real‐time metabolic rocesses occurring in vivo using 13 C‐…
method to non‐invasively study real‐time metabolic rocesses occurring in vivo using 13 C‐…