1. Barratt A, Wyer PC, Hatala R, et al; Evidence-Based Medicine Teaching Tips Working
Group. Tips for learners of evidence-based medicine: 1. Relative risk reduction, absolute risk …

1. Barratt A, Wyer PC, Hatala R, et al; Evidence-Based Medicine Teaching Tips Working
Group. Tips for learners of evidence-based medicine: 1. Relative risk reduction, absolute risk …

Investigators who publish their research in medical journals usually report effect measures
in the form of ratios, such as relative risk or rate ratio. It is well known that the magnitude of …

Contributors and sources: All authors have experience in methodological research and
clinical trials, and several authors have compared cohorts of trial protocols with publications …

There is a profound need to recognise the importance of adverse events. In the USA,
adverse drug reactions (ADRs) have been found to be involved with large number of deaths …

The Vioxx scandal encompassed the world's third-largest drug company, Merck, and the
world's most impactful medical journal, 1 the New England Journal of Medicine (nejm), as …

In medical research, it is not unusual that risks are ruled out without any specification the
exact risk that was ruled out. This makes it difficult to balance expected health benefits and …

In order to identify and reduce biases in clinical research, during the last years, several
rigorous methodological methods were applied to clinical trial management. Nevertheless …

Objectives We sought to identify the proportion of systematic reviews of adverse effects
which search for unpublished data and the success rates of identifying unpublished data for …

To be justifiable, clinical trials must test novel hypotheses and produce informative results.
However, many trials fail on this score. A Delphi process was used to establish consensus …