Clinically similar asthma patients may develop airway obstruction by different mechanisms 1,
2. Asthma treatments that specifically interfere with the 5-lipoxygenase (ALOX5) pathway 3, …

Nitrogen oxides (NOx), regarded in the past primarily as toxic air pollutants, have recently
been shown to be bioactive species formed endogenously in the human lung. The relationship …

Physical forces elicit biochemical signalling in a diverse array of cells, tissues and organisms
1 , 2 , 3 , helping to govern fundamental biological processes. Several hypotheses have …

Background Inhaled β-agonists are the most commonly used treatment for asthma, but data
suggest that regularly scheduled use of these agents may have a deleterious effect on the …

Asthma is a serious health problem throughout the world. During the past two decades, many
scientific advances have improved our understanding of asthma and ability to manage and …

In 1979 and 1980, the chemical structures of the material previously known as slow-reacting
substance of anaphylaxis were elucidated as 5(S)- hydroxy- 6(R)-glutathionyl- 7,9-trans-11,…

In today’s Lancet, the INTERHEART study investigators report a well-coordinated study of
risk factors for myocardial infarction in multiple populations. They present hazard ratios and …

The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually
updated evidence-based strategy for asthma management and prevention, which can be …

The pharmacologic activities of leukotrienes C-1 and D(LTC-1 and LTD), constituents of slow
reacting substance of anaphylaxis (SRS-A), were evaluated in vitro on airway contractile …

AI and Machine Learning in Clinical Medicine, 2023 This first article in a series describes the
history of artificial intelligence in medicine; the use of AI in image analysis, identification of …