Background Meta-analyses are now widely used to provide evidence to support clinical
strategies. However, large randomized, controlled trials are considered the gold standard in …

Context.—Although clinical trials have demonstrated the benefits of lipid-lowering therapy,
little is known about how these drugs are prescribed or used in the general population.…

Methods: A single-blind trial was conducted under the direction of the Shanghai Institute of
Hypertension in 1632 subjects aged 60-79 years alternatively allocated to either nifedipine or …

Objective. —To determine whether the use of inhaled and nasal glucocorticoids is associated
with an increased risk of ocular hypertension or open-angle glaucoma. Design. —Case-…

Background During the past 15 years there has been an exponential increase in the number
of prescriptions for lipid-lowering drugs. Uncertainties remain about the long-term impact of …

Background: Morbidity associated with cardiovascular disease is increasing in the HIV-infected
population. We aimed to study the impact of HIV and of antiretrovirals on acute …

OBJECTIVE: To provide Canadian physicians with evidence-based guidelines for the
pharmacologic treatment of hypertensive disorders in pregnancy. OPTIONS: No medication, or …

PURPOSE: Although the short-term safety and tolerability of statins has been well established,
their potential carcinogenicity in the long term is still debated. The goal of this study was …

… Jacques LeLorier provided access to the data. … We thank Jacques Barry of the Regie
de 1'assurance maladie du Quebec for help with the database and Francois Derderian and …

Abstract Although administrative health care databases have long been used to evaluate
adverse drug effects, responses to drug safety signals have been slow and uncoordinated. We …