Objective To characterise the determinants, time course, and risks of acute myocardial
infarction associated with use of oral non-steroidal anti-inflammatory drugs (NSAIDs). Design …

… Nandini Dendukuri, Maurice McGregor and James Brophy were responsible for interpreting
the data and drafting the paper. Vania Costa was responsible for revising the paper. All of …

Background Multiple randomized controlled trials (RCTs) have examined the cardiovascular
effects of omega-3 fatty acids and have provided unexplained conflicting results. A meta-…

Background Drug-eluting stents (DES) are associated with lower restenosis rates than bare-metal
stents (BMS), but the benefits and safety of the new devices have not been …

Purpose: Congestive heart failure is an important cause of patient morbidity and mortality.
Although several randomized clinical trials have compared β-blockers with placebo for …

Objectives : The purpose of this study was to determine if statins (hydroxymethylglutaryl
CoA reductase inhibitors [HMG-CoA]), angiotensin-converting enzyme (ACE) inhibitors, and …

Background: Coronary stents are widely used in interventional cardiology, but a current
quantitative systematic overview comparing routine coronary stenting with standard …

Standard statistical analyses of randomized clinical trials fail to provide a direct assessment
of which treatment is superior or the probability of a clinically meaningful difference. A …

… Brophy is a funded researcher from Le Fonds de la Recherche en Santé du Québec. Dr.
Yusuf holds a Senior Scientist Award of the Canadian Institutes of Health Research and is an …

… With chapters devoted to reading, singing, public space, carnival, violence and religion,
James Brophy argues that popular culture played a critical role in linking ordinary Rhinelanders …