BACKGROUND: Airway inflammation is considered to be important in asthma but is relatively
inaccessible to study. Less invasive methods of obtaining sputum from patients unable to …

Methods to examine sputum for indices of airway inflammation are evolving. We have
examined the repeatability and the validity of an improved method to measure sputum cells and …

Non‐allergic bronchial hyper‐reactivity is a feature of most patients with asthma. We have
measured non‐allergic bronchial reactivity to inhaled histamine and methacholine in thirteen …

Sputum cell-counts were studied in 7 non-smokers with corticosteroid-responsive chronic
cough productive of sputum and 8 smokers with a clinical diagnosis of chronic bronchitis, all of …

… ‘j’ Critical studies of membrane potential in hyperresponsive states have not been done.
Gap junctions in airways are labile and were recently demonstrated to be modulated by prod…

A reliable predictor of benefit from corticosteroid treatment in patients with chronic airflow
limitation is needed. In a single-blind, sequential crossover trial of placebo and prednisone (30 …

Background: The objectives of the study were to evaluate impairment in quality of life in 12-
to 17-year-old patients with seasonal allergic rhinoconjunctivitis and to develop and test a …

Sputum examination is being used increasingly as a noninvasive method to assess airway
inflammation. Expectorated sputum has variable contamination with saliva. Methods of …

• Seventeen patients, constituting 12.1% of 140 consecutively seen cases of chronic urticaria,
demonstrated thyroid autoimmunity with thyroid microsomal antibodies (TMAs) in serum …

… Pizzichini MMM, PopovTA, Efthimiadis A, Hussack P, Evans S, Pizzichini E, Dolovich J,Har…
Girgis-Gabardo, JA Denburg, FE Hargreave, and J. Dolovich. 1992. Use of induced sputum …