Drugs that promote the association of protein complexes are an emerging therapeutic
strategy. We report discovery of a G protein-coupled receptor (GPCR) ligand that stabilizes an …

We demonstrate that arylchlorodiazirines serve as photo‐activated halocarbene precursors
for the selective one‐carbon ring expansion of N‐substituted pyrroles and indoles to the …

Formation of new C(sp 3 )–C(sp 3 ) bonds is a powerful synthetic tool to increase molecular
diversity, which is highly sought after in medicinal chemistry. Traditional generation of …

… A grade 3/6 systolic murmur was present over all the chest and it was realized in retrospect
that a … Femoral and brachial arterial pulses were diminished, there was a grade 2/6 …

… is compared in subjects with normal and abnormal exercise electrocardiograms in Table
4. For this purpose, electrocardiograms belonging in Group A or Bi and 2 were classified as '…

… The method utilises a low loading (0.5%) of a commercial catalyst system ([Ru(p-cymene)Cl2]2
and DPEPhos), reagent grade solvent and is selective for primary alcohols. Successful …

The clinical course and the results of laboratory investigations of 5 children withunilateral
hyperlucent lung syndrome are presented. This syndrome appears to be an acquired disease …

Maximal treadmill tests following the Bruce protocol were performed by 830 children with heart
defects and the endurance times compared with normal values from 327 children seen in …

A continuous flow method for the selective oxidation of secondary alcohols is reported. The
method is based on an Oppenauer-type ruthenium-catalyzed hydrogen-transfer process that …

… All solvents were of ACS grade. Reactions were performed under an air atmosphere unless
otherwise indicated. H NMR and 13 C NMR data for characterization of compounds were …