User profiles for G. K. Richards

Leland GK Richardson

Massachusetts General Hospital
Verified email at mgh.harvard.edu
Cited by 132

Treatment of perforated diverticular disease of the colon.

EJ Hinchey, PG Schaal, GK Richards - Advances in surgery, 1978 - europepmc.org
Diverticular disease of the colon now is recognized to be functional disease resulting from
altered neuromuscular activity in the colon. Inflammatory complications, when they occur, …

The influence of oral versus parenteral preoperative metronidazole on sepsis following colon surgery

YM Dion, GK Richards, JJ Prentis… - Annals of surgery, 1980 - journals.lww.com
The incidence of wound infection following surgery on the colon is reduced by the preoperative
administration of appropriate antibiotics. Quantitative bacteriologic studies raise the …

Natural History of Chronic Staphylococcus epidermidis Foreign Body Infection in a Mouse Model

…, RF Gagnon, R Subang, GK Richards - Journal of Infectious …, 1991 - academic.oup.com
The development and characterization of a mouse model of chronic Staphylococcus
epidermidis foreign body infection was done with two clinical isolates that differed in degree …

Time-kill efficacy of antibiotics in combination with rifampin against Staphylococcus epidermidis biofilms.

RF Gagnon, GK Richards… - Advances in Peritoneal …, 1994 - europepmc.org
Infections associated with implants are frequently resistant to conventional antibiotic therapy.
This resistance has been ascribed to the presence of bacteria on the artificial surface within …

Penicillin tolerance of human isolates of group C streptococci

D Portnoy, J Prentis, GK Richards - Antimicrobial Agents and …, 1981 - Am Soc Microbiol
Seventeen clinical isolates of group C streptococci were tested for penicillin tolerance. Sixteen
of the strains showed penicillin tolerance with a 32-fold or greater difference between the …

The effect of metronidazole on the incidence of postoperative wound infection in elective colon surgery

C Brass, GK Richards, J Ruedy, J Prentis… - The American Journal of …, 1978 - Elsevier
A prospective randomized clinical trial assessing the relative effectiveness of erythromycin-neomycin
and metronidazole-neomycin as a preoperative bowel preparation was carried out. …

Pulmonary bacterial clearance and alveolar macrophage function in septic shock lung

…, DS Mulder, GK Richards… - American Review of …, 1984 - atsjournals.org
The association between the pulmonary bacterial clearance and the development of septic
shock lung has been demonstrated in porcine and canine experimental models. In order to …

Altered cancer metabolism and implications for next-generation CAR T-cell therapies

…, G Vandecandelaere, LGK Richardson… - Pharmacology & …, 2024 - Elsevier
This review critically examines the evolving landscape of chimeric antigen receptor (CAR) T-cell
therapy in treating solid tumors, with a particular focus on the metabolic challenges …

Increased incidence of experimental colon cancer associated with long-term metronidazole therapy

DA Sloan, DM Fleiszer, GK Richards, D Murray… - The American Journal of …, 1983 - Elsevier
Using the well-established DMH model for colon neoplasia, we demonstrated that a high-fiber
diet pair-fed to animals was associated both with certain changes in bacterial profile and …

Endorphins in septic shock: hemodynamic and endocrine effects of an opiate receptor antagonist and agonist

…, RCJ Chiu, EJ Hinchey, GK Richards - Archives of …, 1982 - jamanetwork.com
• The pathophysiological role of endorphins in septic shock was studied in a porcine model.
Septic shock was induced by the intravenous infusion of liveEscherichia coli.Naloxone …