Sildenafil: from the bench to the bedside

E Michelakis, W Tymchak, S Archer - Cmaj, 2000 - Can Med Assoc
ERECTILE DYSFUNCTION AFFECTS A LARGE SEGMENT of the male population, and in
most cases impaired relaxation of the smooth muscle cells in the corpus cavernosum and …

Sildenafil: a review of its use in erectile dysfunction

HD Langtry, A Markham - Drugs, 1999 - Springer
Sildenafil is an oral therapy for erectile dysfunction of a broad range of causes. By
selectively inhibiting phosphodiesterase type 5, it allows corpus cavernosum smooth muscle …

Sildenafil

J Cartledge, I Eardley - Expert Opinion on Pharmacotherapy, 1999 - Taylor & Francis
Sildenafil (Viagra™, Pfizer, Inc.) is a new orally effective therapy for the treatment of men
with erectile dysfunction (ED). It is a specific and selective inhibitor of phosphodiesterase …

Pharmacotherapy for erectile dysfunction

TJ Bivalacqua, HC Champion, WJG Hellstrom… - Trends in …, 2000 - cell.com
Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an
erection for satisfactory sexual relations. An estimated 20–30 million men suffer from some …

Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor:: research and clinical implications in erectile dysfunction

RB Moreland, I Goldstein, NN Kim, A Traish - Trends in endocrinology & …, 1999 - cell.com
Under normal physiological conditions, following sexual stimulation, release of nitric oxide
(NO) from penile non-adrenergic, non-cholinergic nerves and the endothelium activates …

Sildenafil: a 4-year update in the treatment of 20 million erectile dysfunction patients

CC Carson III - Current Urology Reports, 2003 - Springer
Sildenafil citrate, the first internationally approved and widely used oral agent for the
treatment of erectile dysfunction (ED), has revolutionized the treatment of ED throughout the …

Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction

SH Francis, JD Corbin - Expert opinion on drug metabolism & …, 2005 - Taylor & Francis
Sildenafil citrate is marketed under the trademark name Viagra® and is widely used to treat
male erectile dysfunction; therapeutic uses of this medication for other diseases related to …

Use of oral sildenafil [Viagra] in the treatment of erectile dysfunction

MR Licht - Comprehensive therapy, 1999 - Springer
Conclusions In response to sexual stimulation, sildenafil effectively potentiates the natural
dilatation of arteries supplying blood to the penis and corpora cavernosa. The drug is well …

The pharmacologic management of erectile dysfunction: Sildenafil citrate (Viagra)

H Padma-Nathan - Journal of Sex Education and Therapy, 1998 - Taylor & Francis
Sildenafil citrate (Viagra) is the first effective, orally administered agent for the management
of erectile dysfunction (ED). It is a potent and selective inhibitor of phosphodiesterase type 5 …

Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction

MM Goldenberg - Clinical therapeutics, 1998 - Elsevier
Sildenafil citrate, an oral therapy for erectile dysfunction, is a selective inhibitor of cyclic
guanosine monophosphate (cGMP)—specific phosphodiesterase type 5 (PDE5), the …