Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood flow that
plays an important role in blood pressure (BP) elevation in some models of experimental …

Endothelins are powerful vasoconstrictor peptides that also play numerous other functions
in many different organs. Endothelin-1 (ET-1) is the most abundant and important of this …

Background—Structural and functional alterations of the vasculature may contribute to
complications of hypertension. Because angiotensin II may be pivotal in some of these vascular …

Aldosterone causes nongenomic vasoconstriction by activating phospholipase C in
preglomerular afferent arterioles. 18 The endothelium may modulate this vasoconstrictor effect by …

Essential hypertension is characterized by increased peripheral vascular resistance to blood
flow. This resistance results mostly from energy dissipation in small arteries and arterioles. …

ABSTRACT. Endothelial dysfunction is characterized by a shift of the actions of the endothelium
toward reduced vasodilation, a proinflammatory state, and prothrombic properties. It is …

Accelerated cardiovascular disease is a frequent complication of renal disease. Chronic
kidney disease promotes hypertension and dyslipidemia, which in turn can contribute to the …

Objectives : We sought to conduct a systematic review and meta-analysis of the cardiovascular
risk associated with the metabolic syndrome as defined by the 2001 National Cholesterol …

Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways, …

Endothelin-1 (ET-1) is overexpressed in the vascular wall in certain models of experimental
hypertension: deoxycorticosterone acetate salt–treated rats, deoxycorticosterone acetate salt…