Background Sirolimus-eluting stents have been developed to prevent restenosis in the
treatment of coronary artery disease. We investigated the risk of restenosis with use of sirolimus-…

Background The safety of drug-eluting stents has been called into question by recent reports
of increased stent thrombosis, myocardial infarction, and death. Such studies have been …

Objectives : We assessed the safety and effectiveness of the sirolimus-eluting stent (SES) in
treating single de novo long lesions in small native coronary arteries compared to an …

Background Patients with obstructive left main coronary artery disease are usually treated
with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-…

Aims We sought to compare the results obtained from six major platelet function tests in the
assessment of the prevalence of aspirin resistance in patients with stable coronary artery …

Background Long-term outcomes after percutaneous coronary intervention (PCI) with
contemporary drug-eluting stents, as compared with coronary-artery bypass grafting (CABG), in …

Background— Inhibition of the acyl coenzyme A:cholesterol acyltransferase (ACAT) enzyme
may prevent excess accumulation of cholesteryl esters in macrophages. The ACAT inhibitor …

Rapid reperfusion of the infarct-related artery is the cornerstone of therapy for the management
of acute ST-elevation myocardial infarction (STEMI). Canada’s geography presents …

Objectives : Five-year clinical follow-up has been scheduled per protocol by the 4 Cypher (Cordis/Johnson
& Johnson, Warren, New Jersey) sirolimus-eluting stent (SES) versus bare-…

Aims We investigated the comparability of platelet function tests in quantifying platelet
inhibition achieved by clopidogrel. Methods and results This pre-specified substudy of a …