A substantial proportion of HIV-1-infected individuals are intravenous drug users (IVDUs)
who abuse opiates. Opioids induce a number of immunomodulatory effects that may directly …

We explored host cell and viral factors which influence the susceptibility of lymphocytes to
immortalization by the Epstein-Barr virus (EBV). We found that immortalization by the B95-8 …

Cells from persons with Bloom syndrome feature an elevated rate of sister-chromatid
exchange (SCE). However, in some affected persons a minority of blood lymphocytes have a …

Cyclin T1 has been identified recently as a regulatory subunit of CDK9 and as a component
of the transcription elongation factor P-TEFb. Cyclin T1/CDK9 complexes phosphorylate the …

The opiates are well-established immunomodulatory factors, and recent evidence suggests
that μ- and δ-opioid receptor ligands alter chemokine-driven chemotactic responses through …

Strong evidence for the direct modulation of the immune system by opioids is well documented.
μ-Opioids have been shown to alter the release of cytokines important for both host …

Background Between 1883 and 1996, thousands of Indigenous children were apprehended
into Canada's Residential School System. Survivors and their descendants have testified to …

BACKGROUND: Young Indigenous people, particularly those involved in the child welfare
system, those entrenched in substance use and those living with HIV or hepatitis C, are dying …

The 3'-deoxyadenosine (cordycepin) analog of (2'-5')oligo(A) [(2'-5')oligoadenylate with a
triphosphate at the 5' end], synthesized enzymatically from cordycepin 5'-triphosphate in lysed …

The G protein–coupled 7 transmembrane (STM) chemoattractant receptors can be inactivated
by heterologous desensitization. Earlier work showed that formly peptide receptor-like 1 (…