W ith the emergence of warfarin-resistant rats the new hydroxycoumarin compounds that
have been developed as potent roden-ticides have gained increasing popularity.'These …

W arfarin is a vitamin K antagonist used in humans as an anticoagulant and inanimals as a
rodenticide.'In response to the current resistance to warfarin by rodents second-generation …

The" superwarfarin" compounds are 4-hydroxy derivatives of coumarin that have increased
activity and a longer duration of action than the parent compound. The superwarfarins are …

Because of the emergence of warfarin resistance in rodents, second-generation
anticoagulants named" superwarfarins" were developed and marketed in over-the-counter …

IN THE past decade, several novel hydroxycoumarin anticoagulants have been developed
as rodenticides. These so-called superwarfarins have been developed to deal with the …

coumarin, is a dicoumarol-like substance with a prolonged and hence cumulative action. It
has been used in clinical medicine because, in addi-tion to being effective orally, it can be …

A female patient with significant coagulopathy is presented for case discussion. This case
represented a presumed Munchausen exposure to commercially available rat poison that …

Superwarfarins consist of two classes of compounds, the 4-hydroxycoumarins and the
indandiones. These compounds have replaced warfarin as an anticoagulant rodenticide …

Physicians must have a high index of suspicion when patients have unexplained
prolongation of the prothrombin time and bleeding in the absence of detectable warfarin …

The newer rodenticides, so called" superwarfarins" or second generation Vitamin Kl
antagonists include brodifacoum, difenacoum, chlorphacinone, and bromodialone. They are …