The International Society for Clinical Densitometry (ISCD) periodically convenes Position
Development Conferences (PDCs) in order to establish standards and guidelines for the …

Background Receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast
differentiation, activation, and survival. The fully human monoclonal antibody denosumab (…

Denosumab is a monoclonal antibody to RANKL. In this randomized, placebo‐controlled
study of 412 postmenopausal women with low BMD, subcutaneous denosumab given every 3 …

Context Globally, one in five men aged >50 years is predicted to experience an osteoporotic
fracture. Because of the treatment gap in osteoporosis and the paucity of bone-forming …

… Hamdy, MD (East Tennessee State University, Johnson City, TN); E. Michael Lewiecki,
MD (New Mexico Clinical Research and Osteoporosis Center, Albuquerque, NM). …

Dual-energy X-ray absorptiometry (DXA) is a technology that is widely used to diagnose
osteoporosis, assess fracture risk, and monitor changes in bone mineral density (BMD). The …

Background Romosozumab, a monoclonal antibody that binds sclerostin, increases bone
formation and decreases bone resorption. Methods We enrolled 7180 postmenopausal …

Sclerostin is a small protein expressed by the SOST gene in osteocytes, bone cells that respond
to mechanical stress applied to the skeleton and appear to play an important role in the …

Context: Vertebral fracture (VF) is the most common type of fragility fracture, yet most VFs are
not clinically apparent. VFs are associated with a significant increase in morbidity, mortality, …

INTRODUCTION: Denosumab is a fully human monoclonal antibody that inhibits receptor
activator of nuclear factor-kappa B ligand (RANKL), an essential mediator of osteoclast …