The distal tubule reabsorbs ∼10% of the filtered Mg 2+ , but this is 70–80% of that delivered
from the loop of Henle. Because there is little Mg 2+ reabsorption beyond the distal tubule, …

Methods We systematically searched the MEDLINE database, for the period 1996 to June
30, 2008, and the Cochrane Library using the terms “vitamin D,”“vitamin D deficiency,”“25-…

The calcium‐sensing receptor (CASR) is a plasma membrane G protein coupled receptor
that is expressed in the parathyroid hormone (PTH) producing chief cells of the parathyroid …

In all species tested, except humans, biological differences between vitamins D 2 and D 3
are accepted as fact. To test the presumption of equivalence in humans, we compared the …

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old
hunter-gatherers from Luxembourg and Sweden. We analysed these and other …

A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in
Ontario, Canada, during 1995–96 was screened for germline mutations in BRCA1 and …

Background: BRCA1 and BRCA2 mutations in general populations and in various types of
cancers have not been well characterized. We investigated the presence of these mutations …

Many women do not receive folic acid supplements before conception. In response, most of
Canada's cereal grain products were being fortified with folic acid by January, 1998, thereby …

Prophylactic oophorectomy (PO) is an option for women at increased risk for ovarian
carcinoma. In this study the value of intensive pathologic examination of PO specimens and …

… David Cole designed and coordinated the study and had overall responsibility for … the
genotype assignments, together with CC Liew and David Hwang who did the genetic sequencing. …