Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE…

A major goal of biomedicine is to understand the function of every gene in the human genome
1 . Loss-of-function mutations can disrupt both copies of a given gene in humans and …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Context The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary
disease is uncertain. Study of CETP genotypes can help better understand the relevance of …

Background— Measurement of B-type natriuretic peptide (BNP) concentration or its precursor
(N-terminal fragment [NT-proBNP]) is recommended in patients with symptoms of left …

Objectives : The purpose of this study was to assess the association of apolipoprotein(a) (apo[a])
isoforms with cardiovascular disease risk. Background : Although circulating lipoprotein(…

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe …