A 40-year-old woman had cryocrystalglobulinemia with IgG2 (K1). To date, 27 other cases of
spontaneous crystallization of a plasma protein have been reported. In all, the protein, a …

Thirty human cryoglobulin precipitates obtained from 21 patients were fixed and examined
by electron microscopy; following biochemical isolation and identification. This study …

The studies of a forty-eight year old man who has a cryoglobulin with unique properties are
presented herein. The cryoglobulin polymerizes to form a gel which interferes with the blood …

A patient with a spontaneously crystallizing IgG paraprotein was found to have leukocytosis
when cell counts were determined by the Coulter Counter Model S. The appearance of large …

T HE phenomenon of precipitation of a serum protein by cold was first thoroughly
investigated by Lerner and Watson and the term cryoglobulinemia was introduced by them …

Introduction Biochemical and biophysical studies in recent years have demonstrated a
steadily widening spectrum of diseases and clinical syndromes related pathogenetically to …

A study of twenty-nine patients with cryoglobulinemia revealed the presence of G
immunoglobulins in eight (generally found in patients with multiple myeloma or idiopathic …

We describe a patient with longstanding arthropathy resembling rheumatoid arthritis (RA)
and cold induced purpura for many years, concomitant with IgG kappa paraproteinemia. At …

A case of essential cryoglobulinemia is presented. The sedimentation constant,
electrophoretic behavior and amino acid analysis of the cryoglobulin are studied and …

It is generally believed that the severity of symptoms associated with cryoglobulinemia is a
function of the concentration of the abnormal protein in the plasma. We have seen two …