Background Uremic pruritus is a common and burdensome symptom afflicting patients with
advanced chronic kidney disease (CKD) and has been declared a priority for CKD research …

Cardiovascular disease (CVD) is a major cause of morbidity and mortality among patients
with chronic renal insufficiency (CRI). β-Adrenergic blockers, acetylsalicylic acid (ASA), …

Background Frailty is a condition characterized by a decline in physical function and functional
capacity. Common symptoms of frailty, such as weakness and exhaustion, are prevalent …

Rationale & Objective Renin-angiotensin-aldosterone system (RAAS) inhibitors are
evidence-based therapies that slow the progression of chronic kidney disease (CKD) but can cause …

Background There is little certainty as to the prevalence of frailty in Canadians in younger
adulthood. This study examines and compares the prevalence of frailty in Canadians 18–79 …

Life participation requiring physical activity and physical function is a key patient-reported
outcome for people receiving peritoneal dialysis (PD). Clinician guidance is required from …

Background Individuals on hemodialysis have low physical function and activity levels.
Clinical trials have shown improvements in these parameters with exercise programming. …

Background Hemodialysis is associated with a high symptom burden that impairs health-related
quality of life and functional status. Effective symptom management is a priority for …

Individuals with kidney failure undergoing maintenance dialysis frequently report a high
symptom burden that can interfere with functioning and diminish life satisfaction. Until recently, …

Background: Frailty, a manifestation of unsuccessful aging, is highly prevalent in people
with chronic kidney disease (CKD) and is associated with comorbid conditions in cross-…