GRADE suggests that examination of 95% confidence intervals (CIs) provides the optimal
primary approach to decisions regarding imprecision. For practice guidelines, rating down the …

This article describes the Grading of Recommendations Assessment, Development, and
Evaluation (GRADE) approach to classifying the direction and strength of recommendations. …

In the GRADE approach, the strength of a recommendation reflects the extent to which we
can be confident that the composite desirable effects of a management strategy outweigh the …

Preparing a review entails many judgments. The focus of the review must be decided. Studies
that are relevant to the focus of the review must be identified, selected for inclusion and …

… Andrew D Oxman, researcher2, … , David Atkins, Hilda Bastian, Hans de Beer, Jan
Brozek, Francoise Cluzeau, Jonathan Craig, Ben Djulbegovic, Yngve Falck-Ytter, Beatrice …

This article is the first of a series providing guidance for use of the Grading of Recommendations
Assessment, Development, and Evaluation (GRADE) system of rating quality of …

Flaws in the design, conduct, analysis, and reporting of randomised trials can cause the
effect of an intervention to be underestimated or overestimated. The Cochrane Collaboration’s …

This article introduces the approach of GRADE to rating quality of evidence. GRADE specifies
four categories—high, moderate, low, and very low—that are applied to a body of evidence…

Background Audit and feedback is widely used as a strategy to improve professional practice
either on its own or as a component of multifaceted quality improvement interventions. This …

Objective To summarise comparisons of randomised clinical trials and non-randomised clinical
trials, trials with adequately concealed random allocation versus inadequately concealed …