Asthma is the most prevalent pediatric chronic disease and affects more than 300 million
people worldwide. Recent evidence in mice has identified a “critical window” early in life where …

Background: The gut microbiota is essential to human health throughout life, yet the acquisition
and development of this microbial community during infancy remains poorly understood. …

Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and
annually updated a global strategy for asthma management and prevention that has formed …

Context.—Leukotrienes are important mediators of asthma by causing bronchoconstriction,
mucous secretion, and increased vascular permeability. Studies using compounds that block …

Objectives: To provide physicians with current guidelines for the diagnosis and optimal
management of asthma in children and adults, including pregnant women and the elderly, in …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Breastmilk contains a complex community of bacteria that may help seed the infant gut
microbiota. The composition and determinants of milk microbiota are poorly understood. Among …

The effect of treatment of allergic rhinitis with intranasal corticosteroids on lower airway
responsiveness was assessed in a randomized, double-blind, placebo-controlled, crossover …

Asthma is the most common chronic disease of childhood and the leading cause of childhood
morbidity from chronic disease as measured by school absences, emergency department …

Background To address the major methodological issues of reverse causation and selection
bias in epidemiologic studies of antibiotic use in early life and the development of asthma, …