User profiles for Alexandra Binnie
Alexandra BinnieWilliam Osler Health System Verified email at williamoslerhs.ca Cited by 7639 |
[HTML][HTML] Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial
K Ali, T Azher, M Baqi, A Binnie, S Borgia, FM Carrier… - Cmaj, 2022 - Can Med Assoc
Background: The role of remdesivir in the treatment of patients in hospital with COVID-19
remains ill defined in a global context. The World Health Organization Solidarity randomized …
remains ill defined in a global context. The World Health Organization Solidarity randomized …
[HTML][HTML] Psychosocial distress amongst Canadian intensive care unit healthcare workers during the acceleration phase of the COVID-19 pandemic
A Binnie, K Moura, C Moura, F D'Aragon, JLY Tsang - PLoS One, 2021 - journals.plos.org
Intensive care unit healthcare workers (ICU HCW) are at risk of mental health issues during
emerging disease outbreaks. A study of ICU HCW from France revealed symptoms of anxiety …
emerging disease outbreaks. A study of ICU HCW from France revealed symptoms of anxiety …
[HTML][HTML] How the COVID-19 pandemic will change the future of critical care
Coronavirus disease 19 (COVID-19) has posed unprecedented healthcare system challenges,
some of which will lead to transformative change. It is obvious to healthcare workers and …
some of which will lead to transformative change. It is obvious to healthcare workers and …
Promoter proximal splice sites enhance transcription
Reconstruction of a gene with its introns removed results in reduced levels of cytoplasmic
mRNA. This is partly explained by introns promoting the export of mRNA through coupling …
mRNA. This is partly explained by introns promoting the export of mRNA through coupling …
Effect of probiotics on incident ventilator-associated pneumonia in critically ill patients: a randomized clinical trial
…, B Reeve, F Lellouche, P Hosek, J Tsang, A Binnie… - Jama, 2021 - jamanetwork.com
Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …
questions about the therapeutic potential of microbiome modification with probiotics. Prior …
Epigenetic profiling in severe sepsis: a pilot study of DNA methylation profiles in critical illness
Objectives: Epigenetic alterations are an important regulator of gene expression in health
and disease; however, epigenetic data in sepsis are lacking. To demonstrate proof of concept …
and disease; however, epigenetic data in sepsis are lacking. To demonstrate proof of concept …
Epigenetics of sepsis
Objectives: Recent evidence from the fields of microbiology and immunology, as well as a
small number of human sepsis studies, suggest that epigenetic regulation may play a central …
small number of human sepsis studies, suggest that epigenetic regulation may play a central …
[HTML][HTML] Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers
BP de Almeida, JD Apolónio, A Binnie… - BMC cancer, 2019 - Springer
Background Breast cancer is a highly heterogeneous disease resulting in diverse clinical
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is …
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is …
Biomarkers in acute respiratory distress syndrome
A Binnie, JLY Tsang… - Current opinion in critical …, 2014 - journals.lww.com
This article summarizes the current status of ARDS biomarker research and provides a
framework for future investigation.
framework for future investigation.
[HTML][HTML] CRISPR-based strategies in infectious disease diagnosis and therapy
A Binnie, E Fernandes, H Almeida-Lousada… - Infection, 2021 - Springer
Purpose CRISPR gene-editing technology has the potential to transform the diagnosis and
treatment of infectious diseases, but most clinicians are unaware of its broad applicability. …
treatment of infectious diseases, but most clinicians are unaware of its broad applicability. …