Abstract
Trimethoprim-sulfamethoxazole (TMP-SMX) caused no significant changes in the blood glucose or insulin concentrations of diabetic subjects treated by dietary measures alone or by insulin and diet. In only one of eight subjects receiving oral hypoglycemic agents for the control of diabetes did a significant immediate increase in immunoreactive insulin follow administration of TMP-SMX. In the same patient hypoglycemic symptoms were present after the agent had been taken for 14 days.
MeSH terms
-
Administration, Oral
-
Blood Glucose*
-
Diabetes Mellitus / blood*
-
Diabetes Mellitus / diet therapy
-
Diabetes Mellitus / drug therapy
-
Drug Combinations
-
Humans
-
Hypoglycemic Agents / adverse effects
-
Hypoglycemic Agents / therapeutic use
-
Insulin / blood*
-
Insulin / therapeutic use
-
Sulfamethoxazole / administration & dosage
-
Sulfamethoxazole / adverse effects*
-
Trimethoprim / administration & dosage
-
Trimethoprim / adverse effects*
Substances
-
Blood Glucose
-
Drug Combinations
-
Hypoglycemic Agents
-
Insulin
-
Trimethoprim
-
Sulfamethoxazole