Ear lobe bilateral necrosis by levamisole-induced occlusive vasculitis in a pediatric patient

Pediatr Dermatol. 1997 Nov-Dec;14(6):477-9. doi: 10.1111/j.1525-1470.1997.tb00695.x.

Abstract

We describe a bullous-hemorrhagic reaction of the ear lobes in a child with nephrosis after levamisole intake. This drug is used in children as an alternative treatment of corticosteroid-responsive nephrotic syndrome. Histologic evaluation of a lesion revealed necrotizing vasculitis involving mainly the large vessels of the deep plexus. The lesions disappeared 25 days after discontinuation of treatment.

Publication types

  • Case Reports

MeSH terms

  • Adjuvants, Immunologic / adverse effects*
  • Adjuvants, Immunologic / therapeutic use
  • Arterial Occlusive Diseases / chemically induced*
  • Biopsy
  • Child
  • Ear, External / blood supply
  • Ear, External / pathology*
  • Humans
  • Levamisole / adverse effects*
  • Levamisole / therapeutic use
  • Necrosis
  • Nephrotic Syndrome / drug therapy
  • Skin / blood supply
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Skin Diseases, Vesiculobullous / pathology
  • Vasculitis / chemically induced*
  • Vasculitis / pathology

Substances

  • Adjuvants, Immunologic
  • Levamisole