Abstract
At 32-month follow-up of older patients with prior myocardial infarction, congestive heart failure, and a left ventricular ejection fraction > or = 40% treated with diuretics plus angiotensin-converting enzyme inhibitors, and also with digoxin if atrial fibrillation was present, propranolol caused a 35% significant reduction in total mortality and a 37% significant decrease in total mortality plus nonfatal myocardial infarction compared with no propranolol. At 1-year follow-up, propranolol caused a significantly greater increase in left ventricular ejection fraction (6%) and a significantly greater reduction in left ventricular mass (34 g) than did no propranolol (2% and 20 g, respectively).
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adrenergic beta-Antagonists / pharmacology
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Adrenergic beta-Antagonists / therapeutic use*
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Aged
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Aged, 80 and over
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Angiotensin-Converting Enzyme Inhibitors / therapeutic use
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Diuretics / therapeutic use
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Female
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Heart Failure / complications
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Heart Failure / drug therapy*
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Heart Failure / physiopathology
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Humans
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Incidence
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Male
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Middle Aged
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Mortality*
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Myocardial Infarction / complications
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Myocardial Infarction / epidemiology*
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Myocardial Infarction / prevention & control
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Propranolol / pharmacology
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Propranolol / therapeutic use*
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Stroke Volume / drug effects
Substances
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Adrenergic beta-Antagonists
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Angiotensin-Converting Enzyme Inhibitors
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Diuretics
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Propranolol