Abstract
Exposure of herpes simplex virus (HSV) latently infected subjects to ultraviolet irradiation (UVR) (1 minimum erythema dose, 90% body surface) caused a significant inhibition of HSV and phytohemagglutinin-induced lymphoproliferation. The inhibition was observed on Day 3 post-UVR and lasted at least 9 days. UVR-induced downregulation of HSV-specific lymphoproliferation was associated with increased levels of activated transforming growth factor beta. However, the relationship between UVR-induced immune downregulation and the development of recurrent HSV lesions was incomplete.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Animals
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Cell Line
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Chlorocebus aethiops
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Cytokines / physiology*
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Female
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Herpes Simplex / immunology*
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Humans
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Interleukin-10 / physiology
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Interleukin-6 / physiology
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Lymphocyte Activation / radiation effects*
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Male
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Middle Aged
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Phytohemagglutinins
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Skin / immunology
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Skin / radiation effects*
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Transforming Growth Factor beta / physiology
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Tumor Cells, Cultured
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Ultraviolet Rays*
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Vero Cells
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Virus Latency / immunology
Substances
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Cytokines
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Interleukin-6
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Phytohemagglutinins
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Transforming Growth Factor beta
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Interleukin-10