Abstract
Four patients with acute nonlymphocytic leukemia developed one or more components of the "ara-C syndrome" including fever, peritonitis, pericarditis, and a maculopapular rash during therapy with continuous infusions of low-dose (20 mg/m2/d) cytosine arabinoside (ara-C). These complications, described with standard and high doses of ara-C, have not been previously noted with low-dose regimens.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Cytarabine / administration & dosage
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Cytarabine / adverse effects*
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Female
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Fever / chemically induced
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Humans
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Infusions, Intravenous
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Leukemia / drug therapy*
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Male
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Middle Aged
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Pericarditis / chemically induced
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Peritonitis / chemically induced
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Skin Diseases / chemically induced
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Syndrome