Comparative amnestic effects of benzodiazepine hypnotic agents

J Clin Psychiatry. 1988 Apr;49(4):134-7.

Abstract

The effects of triazolam 0.5 mg and temazepam 30 mg on immediate and delayed recall in normal and insomniac subjects were evaluated in three separate, randomized, placebo-controlled, parallel group studies. Neither drug caused significant impairment of immediate recall. In the tests of delayed recall, triazolam caused a consistent anterograde amnestic effect. No significant impairment of delayed recall was observed in the temazepam study. Anterograde amnesia is thought to be a dose-related effect of benzodiazepines. Compounds with high benzodiazepine receptor affinity such as triazolam are thought to cause this type of amnesia more often than the lower-affinity compounds such as temazepam.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Amnesia / chemically induced*
  • Anti-Anxiety Agents / adverse effects*
  • Dose-Response Relationship, Drug
  • Humans
  • Memory, Short-Term / drug effects
  • Mental Recall / drug effects
  • Sleep Initiation and Maintenance Disorders / drug therapy
  • Temazepam / administration & dosage
  • Temazepam / adverse effects*
  • Temazepam / pharmacology
  • Triazolam / administration & dosage
  • Triazolam / adverse effects*
  • Triazolam / pharmacology

Substances

  • Anti-Anxiety Agents
  • Triazolam
  • Temazepam