Interaction between antiretroviral drugs and acenocoumarol

Antivir Ther. 2011;16(2):249-52. doi: 10.3851/IMP1714.

Abstract

The authors report a case of an HIV type-1-infected patient concomitantly using highly active antiretroviral therapy and acenocoumarol anticoagulant for secondary prevention of recurrent venous thromboembolism. This is the first report of a possible drug interaction between efavirenz and atazanavir/ritonavir with acenocoumarol and also of the uncomplicated concurrent use of raltegravir with acenocoumarol.

Publication types

  • Case Reports

MeSH terms

  • Acenocoumarol / therapeutic use*
  • Alkynes
  • Anti-HIV Agents / therapeutic use*
  • Anticoagulants / therapeutic use*
  • Atazanavir Sulfate
  • Benzoxazines / therapeutic use
  • Cyclopropanes
  • Drug Interactions
  • Drug Therapy, Combination
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Infections / virology
  • Humans
  • Male
  • Middle Aged
  • Oligopeptides / pharmacokinetics
  • Oligopeptides / therapeutic use
  • Pyridines / pharmacokinetics
  • Pyridines / therapeutic use
  • Pyrrolidinones / pharmacokinetics
  • Pyrrolidinones / therapeutic use
  • Raltegravir Potassium
  • Reverse Transcriptase Inhibitors / therapeutic use*
  • Ritonavir / pharmacokinetics
  • Ritonavir / therapeutic use
  • Venous Thrombosis / complications
  • Venous Thrombosis / drug therapy*

Substances

  • Alkynes
  • Anti-HIV Agents
  • Anticoagulants
  • Benzoxazines
  • Cyclopropanes
  • Oligopeptides
  • Pyridines
  • Pyrrolidinones
  • Reverse Transcriptase Inhibitors
  • Raltegravir Potassium
  • Atazanavir Sulfate
  • Acenocoumarol
  • efavirenz
  • Ritonavir