Abstract
The authors report a case of an HIV type-1-infected patient concomitantly using highly active antiretroviral therapy and acenocoumarol anticoagulant for secondary prevention of recurrent venous thromboembolism. This is the first report of a possible drug interaction between efavirenz and atazanavir/ritonavir with acenocoumarol and also of the uncomplicated concurrent use of raltegravir with acenocoumarol.
MeSH terms
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Acenocoumarol / therapeutic use*
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Alkynes
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Anti-HIV Agents / therapeutic use*
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Anticoagulants / therapeutic use*
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Atazanavir Sulfate
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Benzoxazines / therapeutic use
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Cyclopropanes
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Drug Interactions
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Drug Therapy, Combination
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HIV Infections / complications*
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HIV Infections / drug therapy
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HIV Infections / virology
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Humans
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Male
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Middle Aged
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Oligopeptides / pharmacokinetics
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Oligopeptides / therapeutic use
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Pyridines / pharmacokinetics
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Pyridines / therapeutic use
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Pyrrolidinones / pharmacokinetics
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Pyrrolidinones / therapeutic use
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Raltegravir Potassium
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Reverse Transcriptase Inhibitors / therapeutic use*
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Ritonavir / pharmacokinetics
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Ritonavir / therapeutic use
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Venous Thrombosis / complications
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Venous Thrombosis / drug therapy*
Substances
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Alkynes
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Anti-HIV Agents
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Anticoagulants
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Benzoxazines
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Cyclopropanes
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Oligopeptides
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Pyridines
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Pyrrolidinones
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Reverse Transcriptase Inhibitors
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Raltegravir Potassium
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Atazanavir Sulfate
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Acenocoumarol
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efavirenz
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Ritonavir