Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine

J Clin Endocrinol Metab. 2005 Jul;90(7):4057-62. doi: 10.1210/jc.2004-2344. Epub 2005 Apr 26.

Abstract

Background: Neuromuscular symptoms and impaired muscle energy metabolism have been described in subclinical hypothyroidism (sHT).

Aim: The aim of the study was to evaluate the energy and substrate response to exercise in sHT patients using a standardized protocol and to test the effect of L-T(4) replacement in a double-blind, randomized, placebo-controlled fashion.

Patients and methods: We studied 23 sHT patients and 10 matched euthyroid controls. Oxygen uptake (VO(2)), carbon dioxide output, and heart rate were measured during incremental step-up exercise. Blood glucose, lactate, pyruvate, free fatty acid, glycerol, and beta-hydroxybutyrate concentrations were measured at rest, every 2 min during exercise, and during 20 min of recovery. The exercise protocol was repeated after 6 months of placebo or L-T(4)-restored euthyroidism.

Results: Maximal power output (P = 0.02) and VO(2) max (P = 0.04) were reduced in sHT, and, with increasing workload, patients achieved higher heart rates (P < 0.03) at VO(2) values equivalent to those of controls. The respiratory quotient increments were significantly higher in patients than controls (P < 0.04). Blood lactate and pyruvate and their ratio rose with a steeper slope (P < 0.0001, P < 0.001, and P < 0.01, respectively) in patients than controls. Resting plasma free fatty acid and blood glycerol levels were significantly higher in patients than controls (P < 0.0003 and P < 0.003, respectively) throughout baseline, exercise, and recovery. L-T(4) replacement, while improving neuromuscular symptoms, did not produce significant changes in the energy or substrate response to exercise.

Conclusions: The response to exercise is altered both in terms of tolerance and pattern of substrate utilization in sHT patients. Restoring stable euthyroidism does not correct this defect over a 1-yr period.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Double-Blind Method
  • Exercise*
  • Fatty Acids, Nonesterified / blood
  • Female
  • Follow-Up Studies
  • Hormone Replacement Therapy*
  • Humans
  • Hypothyroidism / metabolism*
  • Lactic Acid / blood
  • Male
  • Muscle, Skeletal / metabolism*
  • Oxygen Consumption / drug effects
  • Thyroxine / therapeutic use*

Substances

  • Fatty Acids, Nonesterified
  • Lactic Acid
  • Thyroxine