Abstract
The roles of genetic constitution versus environmental factors in cancer development have been a matter of debate even long before the discovery of 'oncogenes'. Evidence from epidemiological, occupational and migration studies has consistently pointed to environmental factors as the major contributing factors to cancer, so it seems reasonable to discuss the importance of chemical carcinogenesis in the present 'age of cancer genetics'.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Benzo(a)pyrene / chemistry
-
Carcinogens
-
DNA / chemistry
-
DNA Adducts
-
DNA, Complementary / metabolism
-
Environment
-
Humans
-
Hydrocarbons
-
Models, Biological
-
Models, Chemical
-
Mutagens*
-
Mutation
-
Neoplasms / etiology*
-
Neoplasms / genetics*
-
Neoplasms / metabolism
-
Risk
-
Stereoisomerism
Substances
-
Carcinogens
-
DNA Adducts
-
DNA, Complementary
-
Hydrocarbons
-
Mutagens
-
Benzo(a)pyrene
-
DNA