Simplifying drug regimens

HIV Hotline. 1998 Mar;8(1):11.

Abstract

AIDS: In an attempt to simplify antiretroviral regimens, several studies evaluated the use of either indinavir or nelfinavir in twice-daily dosing regimens. Results from a study testing nelfinavir at 750 mg and 1250 mg dosing levels are presented indicating some success with twice-daily therapy, particularly at the 1250 mg level. The indinavir study also shows successful viral load drops using twice-daily regimens. A twice-daily regimen might be considered for patients unable or unwilling to adhere to the thrice-daily regimen. However, long term follow-up studies are needed before switching to twice-daily therapy.

Publication types

  • Newspaper Article

MeSH terms

  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / pharmacokinetics
  • Anti-HIV Agents / therapeutic use
  • Area Under Curve
  • CD4 Lymphocyte Count
  • Drug Administration Schedule
  • HIV Infections / drug therapy*
  • HIV Protease Inhibitors / administration & dosage*
  • HIV Protease Inhibitors / pharmacokinetics
  • HIV Protease Inhibitors / therapeutic use
  • Half-Life
  • Humans
  • Nelfinavir / administration & dosage*
  • Nelfinavir / pharmacokinetics
  • Nelfinavir / therapeutic use
  • Patient Compliance
  • Reverse Transcriptase Inhibitors / administration & dosage*
  • Reverse Transcriptase Inhibitors / pharmacokinetics
  • Reverse Transcriptase Inhibitors / therapeutic use
  • Viral Load

Substances

  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Reverse Transcriptase Inhibitors
  • Nelfinavir