Abstract
Potential hepatotoxicity related to amiodarone therapy is often a concern when deciding whether to initiate or continue treatment with this medication. While mostly associated with long-term oral administration of the drug, toxicity has also been reported early during intravenous administration and months after discontinuation of therapy. In the majority of patients, it is discovered incidentally during routine testing of liver biochemistry and rarely do the hepatic effects develop into symptomatic liver injury or failure. Despite the widespread use of amiodarone, prospective clinical studies have been sparse and there has been little consensus among experts in the field regarding optimum monitoring for adverse effects in patients receiving this drug. In order to examine the current state of knowledge surrounding the incidence, pathogenesis and mechanism of liver effects associated with amiodarone, the existing literature was reviewed, with particular emphasis on clinical recommendations for monitoring.
Keywords: Amiodarone, liver disease, adverse effects, toxicity, drug-induced, liver chemistry, histology, monitoring
Current Vascular Pharmacology
Title: Amiodarone Hepatotoxicity
Volume: 6 Issue: 3
Author(s): Mohamed Babatin, Samuel S. Lee and P. Timothy Pollak
Affiliation:
Keywords: Amiodarone, liver disease, adverse effects, toxicity, drug-induced, liver chemistry, histology, monitoring
Abstract: Potential hepatotoxicity related to amiodarone therapy is often a concern when deciding whether to initiate or continue treatment with this medication. While mostly associated with long-term oral administration of the drug, toxicity has also been reported early during intravenous administration and months after discontinuation of therapy. In the majority of patients, it is discovered incidentally during routine testing of liver biochemistry and rarely do the hepatic effects develop into symptomatic liver injury or failure. Despite the widespread use of amiodarone, prospective clinical studies have been sparse and there has been little consensus among experts in the field regarding optimum monitoring for adverse effects in patients receiving this drug. In order to examine the current state of knowledge surrounding the incidence, pathogenesis and mechanism of liver effects associated with amiodarone, the existing literature was reviewed, with particular emphasis on clinical recommendations for monitoring.
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Cite this article as:
Babatin Mohamed, Lee S. Samuel and Pollak Timothy P., Amiodarone Hepatotoxicity, Current Vascular Pharmacology 2008; 6 (3) . https://dx.doi.org/10.2174/157016108784912019
DOI https://dx.doi.org/10.2174/157016108784912019 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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