Chest
Clinical InvestigationsUsual Interstitial Pneumonia Following Texas A2 Influenza Infection
Section snippets
CASE 1
A 63-year-old nonsmoking man was admitted to the intensive care unit with a flu-like syndrome for one week’s duration. Chest roentgenogram obtained one week before admission was normal, and past medical history was noncontributory.
Physical examination on admission revealed cyanosis and resting dyspnea. Blood pressure was 110/60 mm Hg, pulse, 110 and regular; respiratory rate, 24; temperature, 39°C; and examination of the chest showed diffuse rales. Arterial blood gas levels (FIo2, 0.3 by
COMMENTS
Despite many studies documenting pulmonary damage secondary to acute influenza infection, few data are available on the long-term pulmonary parenchymal changes caused by this agent. In one of the more recent studies, Laraya-Cuassay et al7 described interstitial lung disease in biopsy specimens taken from three children, aged 5, 24, and 42 months, at 50, 166, and 51 days after the onset of the influenza pneumonia. Pathologic findings included a variable degree of bronchial and bronchiolar
REFERENCES (13)
- et al.
Fatal diffuse influenza pneumonia: premortem diagnosis by lung biopsy.
Chest
(1973) - et al.
Desquamative interstitial pneumonia.
Am J Med
(1965) - et al.
Studies on influenza in the pandemic of 1957-1958: II. Pulmonary complications of influenza.
J Clin Invest
(1959) - et al.
Goodpasture’s syndrome associated with influenza A2 virus infection.
Ann Intern Med
(1972) - et al.
Clinicopathologic study of thirty-three fatal cases of Asian influenza.
N Engl J Med
(1959) - et al.
Hong Kong influenza: clinical microbiologic, and pathologic features in 127 cases.
JAMA
(1970)
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