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Genetic variability in response to infection: malaria and after

Genes & Immunity volume 3, pages 331–337 (2002)Cite this article

Abstract

Recent studies have shown that the relatively short period of exposure of human populations to malaria has left in its wake a wide range of genetic diversity. And there is growing evidence that other infectious agents have, or are, having the same effect. By integrating further studies of human populations with genetic analyses of susceptibility to murine malaria it should now be possible to determine some of the mechanisms involved in the variation of susceptibility to infectious disease, information which may have important practical implications for both the diagnosis and better management of these conditions.

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Acknowledgements

We thank Liz Rose for typing this manuscript.

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  1. Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK

    D J Weatherall & J B Clegg

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  1. D J Weatherall
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Correspondence to D J Weatherall.

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The authors’ work was supported by the Medical Research Council and The Wellcome Trust.

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Weatherall, D., Clegg, J. Genetic variability in response to infection: malaria and after. Genes Immun 3, 331–337 (2002). https://doi.org/10.1038/sj.gene.6363878

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